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hirae encode essentially the same Cu I -specific P 1B-1 -type ATPase efflux transporter (Section 5.3) whose Cu I -inducible transcription is regulated by three structurally distinct Cu I -sensing metallosensors, CsoR, 203 CueR (a MerR family member), 249 and CopY, 200 respectively
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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
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